Successful treatment of methicillin-resistant Staphylococcus aureus endocarditis with telavancin.

tomycin levels of 70% of serum is similar. In this case, however, daptomycin was assayed opportunistically, as the patient required repeat knee aspiration for culture after 2 weeks of therapy. It is probable, therefore, that the concentration of daptomycin in synovial fluid reflects either steady-state concentration or accumulation at the site of infection. The therapeutic daptomycin concentration at the site of infection in synovial fluid associated with clinical improvement when used in combination with sodium fusidate add to the data of daptomycin’s utility in osteoarticular infection. The efficacy of daptomycin in osteoarticular infections should be addressed prospectively in sufficiently powered, randomized, controlled trials.